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Two biophysicists have used supercomputers to show how cell membranes control the shape, and consequently the function, of a major cancer-causing protein. The protein, a small enzyme called K-Ras, is attached to cell membranes where it senses signals that originate outside the cell. During cancer, dysfunctional K-Ras then activates proteins inside the cell that can cause tumor growth and metastasis. K-Ras functions as a troublesome molecular switch, which is perpetually "on" in many cancers, particularly pancreatic cancer. The study not only offers a novel method to study K-Ras, which is only 1/100,000th of an inch across, but also shows how the protein's geometry could explain its role in cancer progression. flower girl outfits of tulle

Computer modeling reveal how cell membrane lipids orient cancer-causing proteins http://sciencemission.com/data/attachment.php?id=4366 ()sciencemission.com